Paul passed through Derbe on his route from Cilicia to Iconium, on his second missionary journey (Acts 16:1), and probably also on his third journey (18:23; 19:1). On his first journey (14:20, 21) he came to Derbe from the other side; i.e., from Iconium. It was the native place of Gaius, one of Paul’s companions (20:4). He did not here suffer persecution (2 Tim. 3:11).